abstract：BACKGROUND:No satisfactory neurophysiological test for nociceptive afferents is available to date. Laser stimuli present risks of skin damage, whilst electrical stimulation through specially designed electrodes is not selective enough. NEW METHOD:We present a new electrode designed according to critical issues identif...

journal_title：Journal of neuroscience methods

authors： Leandri M,Marinelli L,Siri A,Pellegrino L

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The light-induced release of neurotransmitters from caging chromophores provides a powerful means to study the underlying receptors in a physiologically relevant context. Surprisingly, most caged neurotransmitters, including the widely used 4-methoxy-7-nitroindolinyl (MNI)-glutamate, show strong antagonism a...

journal_title：Journal of neuroscience methods

authors： Passlick S,Ellis-Davies GCR

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Tree shrews are proposed as an alternative animal model to nonhuman primates due to their close affinity to primates. Neuroimaging techniques are widely used to study brain functions and structures of humans and animals. However, tree shrews are rarely applied in neuroimaging field partly due to the lack of ...

journal_title：Journal of neuroscience methods

authors： Huang Q,Nie B,Ma C,Wang J,Zhang T,Duan S,Wu S,Liang S,Li P,Liu H,Sun H,Zhou J,Xu L,Shan B

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Large animal models of human neurological disorders are advantageous compared to rodent models due to their neuroanatomical complexity, longevity and their ability to be maintained in naturalised environments. Some large animal models spontaneously develop behaviours that closely resemble the symptoms of neu...

journal_title：Journal of neuroscience methods

authors： Roberts K,Hemmings AJ,McBride SD,Parker MO

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Virtual reality-based neuropsychological assessments proffer the potential to address the limited ecological validity of pen-and-paper measures of memory. NEW METHOD:To investigate the construct validity of a newly developed virtual reality-based multiple errands task, the Virtual Environment Grocery Store ...

journal_title：Journal of neuroscience methods

authors： Parsons TD,McMahan T

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The frequency-following response (FFR) is a scalp-recorded electrophysiological potential reflecting phase-locked activity from neural ensembles in the auditory system. The FFR is often used to assess the robustness of subcortical pitch processing. Due to low signal-to-noise ratio at the single-trial level, ...

journal_title：Journal of neuroscience methods

authors： Llanos F,Xie Z,Chandrasekaran B

更新日期：2017-11-01 00:00:00

abstract：:Griffanti et al. (2017) provide a rich set of expert-consensus guidelines for how to label components derived from ICA as either belonging to signal of interest or noise to be filtered from fMRI data. These general hypotheses concerning procedures for "hand" classification of components are a good starting point that ...

journal_title：Journal of neuroscience methods

authors： Kelly RE Jr,Alexopoulos GS,Gunning FM,Hoptman MJ

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Single unit recording in behaving nonhuman primates is widely used to study the primate central nervous system. However, certain questions cannot be addressed without recording large numbers of neurons simultaneously. Multiple 96-electrode probes can be implanted at one time, but certain problems must be ove...

journal_title：Journal of neuroscience methods

authors： Mitz AR,Bartolo R,Saunders RC,Browning PG,Talbot T,Averbeck BB

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Wireless neural recording technologies now provide untethered access to large populations of neurons in the nonhuman primate brain. Such technologies enable long-term, continuous interrogation of neural circuits and importantly open the door for chronic neurorehabilitation platforms. For example, by providin...

journal_title：Journal of neuroscience methods

authors： Powell MP,Britz WR,Harper JS 3rd,Borton DA

更新日期：2017-08-15 00:00:00

abstract：BACKGROUND:Large-scale Granger causality (lsGC) is a recently developed, resting-state functional MRI (fMRI) connectivity analysis approach that estimates multivariate voxel-resolution connectivity. Unlike most commonly used multivariate approaches, which establish coarse-resolution connectivity by aggregating voxel ti...

journal_title：Journal of neuroscience methods

authors： DSouza AM,Abidin AZ,Leistritz L,Wismüller A

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:This study analyses multiple spike trains (MST) data, defines its functional connectivity and subsequently visualises an accurate diagram of connections. This is a challenging problem. For example, it is difficult to distinguish the common input and the direct functional connection of two spike trains. NEW ...

journal_title：Journal of neuroscience methods

authors： Masud MS,Borisyuk R,Stuart L

更新日期：2017-07-15 00:00:00

abstract：BACKGROUND:The trigeminal subnucleus caudalis (Vc) plays a critical role in transmission and modulation of nociceptive afferent inputs, and exhibits a similar layer construction to the spinal dorsal horn. However, afferent inputs enter the brainstem and project to a separately located nucleus. It has previously been di...

journal_title：Journal of neuroscience methods

authors： Hirahara M,Fujiwara N,Seo K

更新日期：2017-07-15 00:00:00

abstract：BACKGROUND:CNS inflammation resulting from infection, injury, or neurodegeneration leads to accumulation of diverse B cell subsets. Although antibody secreting cells (ASC) within the inflamed CNS have been extensively examined, memory B cell (Bmem) characterization has been limited as they do not secrete antibody witho...

journal_title：Journal of neuroscience methods

authors： DiSano KD,Stohlman SA,Bergmann CC

更新日期：2017-06-15 00:00:00

abstract：BACKGROUND:Operant training systems make use of water or food restriction and make it necessary to weigh animals to ensure compliance with experimental endpoints. In other applications periodic weighing is necessary to assess drug side-effects, or as an endpoint in feeding experiments. Periodic weighing while essential...

journal_title：Journal of neuroscience methods

authors： Noorshams O,Boyd JD,Murphy TH

更新日期：2017-06-15 00:00:00

abstract：:In vitro and in vivo models of experimental glioma are useful tools to gain a better understanding of glioblastoma (GBM) and to investigate novel treatment strategies. However, the majority of preclinical models focus on treating solid intracranial tumours, despite surgical resection being the mainstay in the standard...

journal_title：Journal of neuroscience methods

authors： Bianco J,Bastiancich C,Joudiou N,Gallez B,des Rieux A,Danhier F

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Currently the problem of incorporating priori information into an independent component analysis (ICA) model is often solved under the framework of constrained ICA, which utilizes the priori information as a reference signal to form a constraint condition and then introduce it into classical ICA. However, it...

journal_title：Journal of neuroscience methods

authors： Shi Y,Zeng W,Wang N,Zhao L

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Neurite outgrowth is a metric widely used to assess the success of in vitro neural stem cell differentiation or neuron reprogramming protocols and to evaluate high-content screening assays for neural regenerative drug discovery. However, neurite measurements are tedious to perform manually, and there is a pa...

journal_title：Journal of neuroscience methods

authors： Long BL,Li H,Mahadevan A,Tang T,Balotin K,Grandel N,Soto J,Wong SY,Abrego A,Li S,Qutub AA

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The human mesenchymal stem cells derived from Wharton's jelly tissue (hWJ-MSCs) represent a tool for cell-based therapies and regenerative medicine. hWJ-MSCs form neurospheres (NSs) within 3-7 days. No data is available to establish the neuro-phenotypic markers and time of formation of nerve-like (NLCs) and ...

journal_title：Journal of neuroscience methods

authors： Bonilla-Porras AR,Velez-Pardo C,Jimenez-Del-Rio M

更新日期：2017-04-15 00:00:00

abstract：BACKGROUND:Intracranial electrical recordings (iEEG) and brain stimulation (iEBS) are invaluable human neuroscience methodologies. However, the value of such data is often unrealized as many laboratories lack tools for localizing electrodes relative to anatomy. To remedy this, we have developed a MATLAB toolbox for int...

journal_title：Journal of neuroscience methods

authors： Groppe DM,Bickel S,Dykstra AR,Wang X,Mégevand P,Mercier MR,Lado FA,Mehta AD,Honey CJ

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The human auditory brainstem frequency-following response (FFR) is an objective measure used to investigate the brainstem's encoding ability of sounds. Traditionally, FFRs are recorded under close-field conditions (earphones), but free-field stimulations (loudspeaker) have yet to be attempted, which would in...

journal_title：Journal of neuroscience methods

authors： Gama N,Peretz I,Lehmann A

更新日期：2017-03-15 00:00:00

abstract：BACKGROUND:Functional magnetic resonance imaging is well suited to link neural population activation with movement parameters of complex natural arm movements. However, currently existing MR-compatible arm tracking devices are not constructed to measure arm joint movement parameters of unrestricted movements. Therefore...

journal_title：Journal of neuroscience methods

authors： Shirinbayan SI,Rieger JW

更新日期：2017-03-15 00:00:00

abstract：BACKGROUND:Motion-onset visual evoked potentials (mVEP) can provide a softer stimulus with reduced fatigue, and it has potential applications for brain computer interface(BCI)systems. However, the mVEP waveform is seriously masked in the strong background EEG activities, and an effective approach is needed to extract t...

journal_title：Journal of neuroscience methods

authors： Ma T,Li H,Yang H,Lv X,Li P,Liu T,Yao D,Xu P

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Negative emotional states resulting from concussion are of increasing concern. In the current study, we developed a model to investigate negative affect following concussion in the projectile concussive impact (PCI) model. High frequency ultrasonic vocalizations (22kHz USVs) are associated with negative affe...

journal_title：Journal of neuroscience methods

authors： Browning JR,Whiteman AC,Leung LY,Lu XM,Shear DA

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Automated segmentation of brain structures is an important task in structural and functional image analysis. We developed a fast and accurate method for the striatum segmentation using deep convolutional neural networks (CNN). NEW METHOD:T1 magnetic resonance (MR) images were used for our CNN-based segmenta...

journal_title：Journal of neuroscience methods

authors： Choi H,Jin KH

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The complexity of analyzing eye-tracking signals increases as eye-trackers become more mobile. The signals from a mobile eye-tracker are recorded in relation to the head coordinate system and when the head and body move, the recorded eye-tracking signal is influenced by these movements, which render the subs...

journal_title：Journal of neuroscience methods

authors： Larsson L,Schwaller A,Nyström M,Stridh M

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Evaluation of motor deficits in rodents is mostly restricted to limb motor tests that are often high stressors for the animals. NEW METHOD:To test rodents for orofacial motor impairments in a stress-free environment, we established the pasta gnawing test by measuring the biting noise of mice that eat a piec...

journal_title：Journal of neuroscience methods

authors： Rabl R,Horvath A,Breitschaedel C,Flunkert S,Roemer H,Hutter-Paier B

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Analysis of individual slow waves in EEG recording during sleep provides both greater sensitivity and specificity compared to spectral power measures. However, parameters for detection and analysis have not been widely explored and validated. NEW METHOD:We present a new, open-source, Matlab based, toolbox f...

journal_title：Journal of neuroscience methods

authors： Mensen A,Riedner B,Tononi G

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Multiscale entropy (MSE) estimates the predictability of a signal over multiple temporal scales. It has been recently applied to study brain signal variability, notably during aging. The grounds of its application and interpretation remain unclear and subject to debate. METHOD:We used both simulated and exp...

journal_title：Journal of neuroscience methods

authors： Courtiol J,Perdikis D,Petkoski S,Müller V,Huys R,Sleimen-Malkoun R,Jirsa VK

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Although the relationship between neuronavigated transcranial magnetic stimulation (nTMS) and functional magnetic resonance imaging (fMRI) has been widely studied in motor mapping, it is unknown how the motor response type or the choice of motor task affect this relationship. NEW METHOD:Centers of gravity (...

journal_title：Journal of neuroscience methods

authors： Kallioniemi E,Pitkänen M,Könönen M,Vanninen R,Julkunen P

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:To optimize survival evaluation of Schwann cells (SCs) in vivo, we tested fluorescent labeling of the nucleus as an improved method of tracking and counting the transplanted SCs at sciatic nerve injury sites in rodents. We also investigated if co-administering cells with the glial growth factor Neuregulin-1 ...

journal_title：Journal of neuroscience methods

authors： Gambhir HS,Raharjo E,Forden J,Kumar R,Mishra C,Guo GF,Grochmal J,Shapira Y,Midha R

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Behavioral analyses in rodents have successfully delineated the function of many genes and signaling pathways in the brain. Behavioral testing uses highly defined experimental conditions to identify abnormalities in a given mouse strain or genotype. The open field (OF) is widely used to assess both locomotio...

journal_title：Journal of neuroscience methods

authors： Dagan SY,Tsoory MM,Fainzilber M,Panayotis N

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Neuroevolution comprises the use of evolutionary computation to define the architecture and/or to train artificial neural networks (ANNs). This strategy has been employed to investigate the behavior of rats in the elevated plus-maze, which is a widely used tool for studying anxiety in mice and rats. NEW MET...

journal_title：Journal of neuroscience methods

authors： Costa AA,Tinós R

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:In neuroscience, relating the spiking activity of individual neurons to the local field potential (LFP) of neural ensembles is an increasingly useful approach for studying rhythmic neuronal synchronization. Many methods have been proposed to measure the strength of the association between spikes and rhythms ...

journal_title：Journal of neuroscience methods

authors： Li Z,Cui D,Li X

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:Electroencephalogram (EEG) signals are often corrupted with unintended artifacts which need to be removed for extracting meaningful clinical information from them. Typically a priori knowledge of the nature of the artifacts is needed for such purpose. Artifact contamination of EEG is even more prominent for ...

journal_title：Journal of neuroscience methods

authors： Bono V,Das S,Jamal W,Maharatna K

更新日期：2016-07-15 00:00:00

abstract：BACKGROUND:The neurological disorder known as epilepsy is characterized by involuntary recurrent seizures that diminish a patient's quality of life. Automatic seizure detection can help improve a patient's interaction with her/his environment, and while many approaches have been proposed the problem is still not trivia...

journal_title：Journal of neuroscience methods

authors： Z-Flores E,Trujillo L,Sotelo A,Legrand P,Coria LN

更新日期：2016-06-15 00:00:00

abstract：BACKGROUND:While several novel therapeutic approaches for HD are in development, resources to conduct clinical trials are limited. Large animal models have been proposed to improve assessment of safety, tolerability and especially to increase translational reliability of efficacy signals obtained in preclinical studies...

journal_title：Journal of neuroscience methods

authors： Schramke S,Schuldenzucker V,Schubert R,Frank F,Wirsig M,Ott S,Motlik J,Fels M,Kemper N,Hölzner E,Reilmann R

更新日期：2016-05-30 00:00:00

abstract：:The number of studies examining cognition in Huntington's disease (HD) has increased dramatically in recent decades, and cognitive research methods in HD have become much more sophisticated. In this review, we provide a summary of the advances in cognitive research in HD to date, and outline the key considerations for...

journal_title：Journal of neuroscience methods

authors： Stout JC,Glikmann-Johnston Y,Andrews SC

更新日期：2016-05-30 00:00:00

abstract：BACKGROUND:For reasons of cost and ethical concerns, models of neurodegenerative disorders such as Huntington disease (HD) are currently being developed in farm animals, as an alternative to non-human primates. Developing reliable methods of testing cognitive function is essential to determining the usefulness of such ...

journal_title：Journal of neuroscience methods

authors： McBride SD,Perentos N,Morton AJ

更新日期：2016-05-30 00:00:00

abstract：BACKGROUND:Multielectrode arrays (MEAs) have been used to understand electrophysiological network dynamics by recording real-time activity in groups of cells. The extent to which the collection of such data enables hypothesis testing on the level of circuits and networks depends largely on the sophistication of the ana...

journal_title：Journal of neuroscience methods

authors： Kim HB,Oh TI,Swanberg KM,Lee MB,Kim TW,Woo EJ,Park JH,Kwon OI

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The widespread use of data-driven methods, such as independent component analysis (ICA), for the analysis of functional magnetic resonance imaging data (fMRI) has enabled deeper understanding of neural function. However, most popular ICA algorithms for fMRI analysis make several simplifying assumptions, thus...

journal_title：Journal of neuroscience methods

authors： Du W,Levin-Schwartz Y,Fu GS,Ma S,Calhoun VD,Adalı T

更新日期：2016-05-01 00:00:00